Preparation and properties of mixed micelles made of Pluronic polymer and PEG-PE

Mixed micelles made of Pluronic P105 (P105) and poly(ethylene glycol)–phosphatidyl ethanolamine conjugate (PEG-PE) were prepared. The interaction of Pluronic and PEG-PE was studied and the interaction parameter β and critical micelle concentration (CMC) were used to evaluate the micellar stability toward dilution. The results showed that certain mixed micelles were more stable than pure Pluronic micelles upon dilution. The mixed micelles were used to trap the poorly soluble anticancer drug camptothecin (CPT). The cytotoxicity of the CPT-loaded mixed micelles against MCF-7 cancer cell was higher than that of CPT-loaded P105 micelles and much higher than that of the free drug.

Mixed micelles made of Pluronic P105 and PEG-PE were prepared. PEG-PE was chosen because the diacyllipid chains of PEG-PE may increase hydrophobic interactions in the micelle's core and thus provide some advantages in micelle stability compared to Pluronic polymers.Figure optionsDownload as PowerPoint slide