کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6146755 1594950 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Randomized clinical trial of imiquimod: an adjunct to treating cervical dysplasia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Randomized clinical trial of imiquimod: an adjunct to treating cervical dysplasia
چکیده انگلیسی

ObjectivesHuman papillomavirus (HPV) infection is a major risk factor for cervical cancer. Imiquimod is a topical medication that enhances the immune response to HPV-induced genital warts. This study evaluated cervical application of imiquimod as an adjunct to standard treatment for cervical dysplasia.Study DesignFifty-six patients were randomized to standard excisional/ablative treatment vs applications of imiquimod followed by standard treatment. The primary endpoint was dysplasia recurrence within 2 years.ResultsThere were no differences in dysplasia recurrence between the 2 groups. Treatment was well tolerated, with side effects being mild but significantly worse in women receiving imiquimod for, chills, fatigue, fever, headache, myalgias, and vaginal discharge.ConclusionThis trial does not support the hypothesis that imiquimod, as used in this trial, has an impact on recurrence of cervical dysplasia, but the adequacy of findings are limited by sample size. The trial does support the feasibility and acceptability of the use of imiquimod on the cervix.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Obstetrics and Gynecology - Volume 206, Issue 1, January 2012, Pages 42.e1-42.e7
نویسندگان
, , , , , , , , , ,