کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6150391 | 1596425 | 2016 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of intermittent calorie restriction on metabolic health: Rationale and study design of the HELENA Trial
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کلمات کلیدی
ICRvolumetric interpolated breath-hold examinationSF-12NCTCAIPIRINHAFFQPALCCRPBMCMRI - امآرآی یا تصویرسازی تشدید مغناطیسیAdipose tissue - بافت چربیGene-expression - بیان ژنMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیHealthy diet - رژیم سالمPhysical activity level - سطح فعالیت فیزیکیPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیFlash - فلاشMetabolism - متابولیسم calorie restriction - محدودیت کالریObesity - مرض چاقیIntermittent fasting - ناگهانی متناوبFFQ, Food Frequency Questionnaire - پرسشنامه بسامد خوراک، پرسشنامه بسامد مصرف غذاییVIBE - پرنیانControlled Aliasing In Parallel Imaging Results In Higher Acceleration - کنترل نامناسبی در نتایج همزمان تصویربرداری در شتاب بیشتر
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Mechanistic studies suggest benefits of intermittent calorie restriction (ICR) in chronic disease prevention that may exceed those of continuous calorie restriction (CCR), even at equal net calorie intake. Despite promising results from first trials, it remains largely unknown whether ICR-induced metabolic alterations reported from experimental studies can also be observed in humans, and whether ICR diets are practicable and effective in real life situations. Thus, we initiated the HELENA Trial to test the effects of ICR (eu-caloric diet on five days and very low energy intake on two days per week) on metabolic parameters and body composition over one year. We will assess the effectiveness of ICR compared to CCR and a control diet over a 12-week intervention, 12-week maintenance phase and 24-week follow-up in 150 overweight or obese non-smoking adults (50 per group, 50% women). Our primary endpoint is the difference between ICR and CCR with respect to fold-changes in expression levels of 82 candidate genes in abdominal subcutaneous adipose tissue biopsies (SATb) during the intervention phase. The candidate genes represent pathways, which may link obesity-related metabolic alterations with the risk for major chronic diseases. In secondary and exploratory analyses, changes in metabolic, hormonal, inflammatory and metagenomic parameters measured in different biospecimens (SATb, blood, urine, stool) are investigated and effects of ICR/CCR/control on imaging-based measures of subcutaneous, visceral and hepatic fat are evaluated. Our study is the first randomized trial over one year testing the effects of ICR on metabolism, body composition and psychosocial factors in humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contemporary Clinical Trials - Volume 51, November 2016, Pages 28-33
Journal: Contemporary Clinical Trials - Volume 51, November 2016, Pages 28-33
نویسندگان
Ruth Schübel, Mirja E. Graf, Johanna Nattenmüller, Diana Nabers, Disorn Sookthai, Laura F. Gruner, Theron Johnson, Christopher L. Schlett, Oyunbileg von Stackelberg, Romy Kirsten, Nina Habermann, Mario Kratz, Hans-Ulrich Kauczor, Cornelia M. Ulrich,