کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6150516 | 1231494 | 2015 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The 'Expanded HIV care in opioid substitution treatment' (EHOST) cluster-randomized, stepped-wedge trial: A study protocol
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کلمات کلیدی
ICCPLHIVPTAPWIDQALYCHCDIN - ازPeople living with HIV - افراد مبتلا به HIVpeople who inject drugs - افرادی که مواد مخدر مصرف می کنندsur - برOat - جو دو سرOpioid agonist treatment - درمان آگونیست اپیوئیدAntiretroviral treatment - درمان ضد رتروویروسیcombination antiretroviral therapy - درمان ضد رتروویروسی ترکیبیQuality Adjusted Life Years - سالهای زندگی سالم تنظیم شدهSeemingly unrelated regression - ظاهرا رگرسیون غیر مرتبطPrimary outcome - نتیجه اولیهART - هنرHIV - ویروس نقص ایمنی انسانی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The 'Expanded HIV care in opioid substitution treatment' (EHOST) cluster-randomized, stepped-wedge trial: A study protocol The 'Expanded HIV care in opioid substitution treatment' (EHOST) cluster-randomized, stepped-wedge trial: A study protocol](/preview/png/6150516.png)
چکیده انگلیسی
The public health response to HIV/AIDS has turned its focus onto optimizing health care system delivery to maximize case identification, access and sustained engagement in antiretroviral treatment (ART). Opioid Agonist Treatment (OAT) provides a critical opportunity for HIV testing and linkage to ART. The EHOST study is a cluster-randomized, stepped-wedge trial to evaluate a prescriber-focused intervention to increase HIV testing rates, and optimize ART engagement and retention outcomes among individuals engaged in OAT. The study will encompass all drug treatment clinics currently admitting patients for the treatment of opioid use disorder across the province of British Columbia, encompassing an estimated 90% of the OAT caseload. The trial will be executed over a 24-month period, with groups of clinics receiving the intervention in 6-month intervals. Evaluation of the proposed intervention's effectiveness will focus on three primary outcomes: (i) the HIV testing rate among those not known to be HIV positive; (ii) the rate of ART initiation among those not on ART; and (iii) the rate of ART continuation among those on ART. A difference-in-differences analytical framework will be applied to estimate the intervention's effect. This approach will assess site-specific changes in primary outcomes across clusters while adjusting for potential residual heterogeneity in patient case mix, volume, and quality of care across clinics. Statistical analysis of outcomes will be conducted entirely with linked population-level administrative health datasets. Facilitated by established collaborations between key stakeholders across the province, the EHOST intervention promises to optimize HIV testing and care within a marginalized and hard-to-reach population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contemporary Clinical Trials - Volume 45, Part B, November 2015, Pages 201-209
Journal: Contemporary Clinical Trials - Volume 45, Part B, November 2015, Pages 201-209
نویسندگان
B. Nosyk, E. Krebs, J.E. Min, K. Ahamad, J. Buxton, C. Goldsmith, M. Hull, R. Joe, M. Krajden, V.D. Lima, M. Olding, E. Wood, J.S.G. Montaner,