Design and conduct of 'Xtreme Alps': A double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude

Results from this study will further elucidate the role of NO in adaption to hypoxaemia and guide clinical trials in critically ill patients. Improved understanding of hypoxaemia in critical illness may provide new therapeutic avenues for interventions that will improve survival in critically ill patients.