کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6151321 | 1231514 | 2013 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Group sequential designs for developing and testing biomarker-guided personalized therapies in comparative effectiveness research
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Group sequential designs for developing and testing biomarker-guided personalized therapies in comparative effectiveness research Group sequential designs for developing and testing biomarker-guided personalized therapies in comparative effectiveness research](/preview/png/6151321.png)
چکیده انگلیسی
Biomarker-guided personalized therapies offer great promise to improve drug development and improve patient care, but also pose difficult challenges in designing clinical trials for the development and validation of these therapies. We first give a review of the existing approaches, briefly for clinical trials in new drug development and in more detail for comparative effectiveness trials involving approved treatments. We then introduce new group sequential designs to develop and test personalized treatment strategies involving approved treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contemporary Clinical Trials - Volume 36, Issue 2, November 2013, Pages 651-663
Journal: Contemporary Clinical Trials - Volume 36, Issue 2, November 2013, Pages 651-663
نویسندگان
Tze Leung Lai, Olivia Yueh-Wen Liao, Dong Woo Kim,