کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6151701 | 1596566 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: C-reactive protein distribution and correlation with traditional cardiovascular risk factors in the Italian population C-reactive protein distribution and correlation with traditional cardiovascular risk factors in the Italian population](/preview/png/6151701.png)
BackgroundC-reactive protein (CRP) increases during an inflammatory response; its plasma levels are believed to be an independent predictor of future atherosclerotic disease. We report the distribution of plasma levels of CRP and its possible relationship with other cardiovascular risk factors in an Italian cohort.MethodsCRP was assessed in frozen plasma samples of 1949 participants in the CHECK study (2001-2005), which collected clinical and biochemical data from randomly selected subjects (40-79 years) in the setting of Italian general practice.ResultsMedian CRP (interquartile range) was higher in women (1.42 [0.58-2.86] vs 1.28 [0.58-2.50]; p = .163), in people aged â¥Â 65 years (1.74 [0.89-3.34] vs 1.11 [0.52-2.45]; p < .001), in patients with obesity (2.37 [1.27-4.15] vs 1.16 [0.52-2.41]; p < .001), metabolic syndrome (2.12 [1.16-3.72] vs 1.10 [0.50-2.38]; p < .001), or higher cardiovascular risk (2.03 [1.01-3.42] vs 1.19 [0.53-2.50]; p < .001). Stepwise regression analysis showed significant associations (R2 = .264) of circulating logeCRP with body mass index, fibrinogen, apoB, age, gender, smoking habits, physical inactivity, creatinine levels, and systolic blood pressure.ConclusionThis study provides epidemiological data of CRP in the Italian population and reinforces the existing evidences about the close correlation between CRP and markers of inflammation and adiposity.
Journal: European Journal of Internal Medicine - Volume 24, Issue 2, March 2013, Pages 161-166