کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6156392 | 1598239 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinical Use of the Urine Biomarker [TIMP-2] à [IGFBP7] for Acute Kidney Injury Risk Assessment
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کلمات کلیدی
Insulin-like growth factor binding protein 7acute kidney injury (AKI) - آسیب حاد کلیه (AKI)Renal dysfunction - اختلال عملکرد کلیهRisk assessment - ارزیابی ریسکcritically ill - بیمار شدیدBiomarker - بیومارکرDiagnosis - تشخیصEarly detection - تشخیص زود هنگامTissue inhibitor of metalloproteinase 2 - مهار کننده بافت متالوپروتئیناز 2decreased kidney function - کاهش عملکرد کلیه
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
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چکیده انگلیسی
Acute kidney injury (AKI) is a serious complication, commonly occurring in the critically ill population, with devastating short- and long-term consequences. Despite standardization of the definition and staging of AKI, early recognition remains challenging given that serum creatinine level is a marker, albeit imperfect, of kidney function and not kidney injury. Furthermore, the delay in increase in serum creatinine level after loss of glomerular filtration also prevents timely detection of decreased kidney function in patients with AKI. During the past decade, numerous clinical investigations have evaluated the utility of several biomarkers in the early diagnosis and risk stratification of AKI. In 2014, the US Food and Drug Administration approved the marketing of a test based on the combination of urine concentrations of tissue inhibitor of metalloproteinase 2 and insulin-like growth factor binding protein 7 ([TIMP-2]Â Ã [IGFBP7]) to determine whether certain critically ill patients are at risk for developing moderate to severe AKI. The optimal role of this biomarker in the diagnosis, management, and prognosis of AKI in different clinical settings requires further clarification. In this perspective, we summarize the biological actions of these 2 cell-cycle arrest biomarkers and present important considerations regarding the clinical application, interpretation, and limitations of this novel test for the early detection of AKI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 68, Issue 1, July 2016, Pages 19-28
Journal: American Journal of Kidney Diseases - Volume 68, Issue 1, July 2016, Pages 19-28
نویسندگان
Anitha MD, Sarah MD, David J. MD, MSPH, Jorge MD, William H. MD, Michael MD, Benjamin D. MD, PhD, Jay L. MD, Kathleen D. MD, PhD, Girish MBBS, MD, Thomas D. PharmD, PhD, Azra MD,