کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
61625 | 47593 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Supported l-proline on zirconium phosphates methyl and/or phenyl phosphonates as heterogeneous organocatalysts for direct asymmetric aldol addition Supported l-proline on zirconium phosphates methyl and/or phenyl phosphonates as heterogeneous organocatalysts for direct asymmetric aldol addition](/preview/png/61625.png)
Zirconium phosphates methyl and/or phenyl phosphonates-supported l-proline have been prepared as amorphous solids by precipitation of (4R)-4-(phosphonooxy)-l-proline, methyl and/or phenyl phosphonic acid with ZrOCl2. The supported l-proline catalysts were tested on the direct asymmetric aldol addition of cyclohexanone to p-nitrobenzaldehyde in DMF/H2O (9:1) and in sole water. The hydrophobic groups on solid surface favor reagents’ diffusion toward proline chiral moiety increasing the catalytic activity of supported l-proline. High diastereoselectivity (anti/syn up to 94:6) and high enantiomeric excess up to 97% have been obtained.
Zirconium phosphates methyl and/or phenyl phosphonates-supported l-proline have been prepared as amorphous solids and their catalytic activity tested on the direct asymmetric aldol addition of cyclohexanone to p-nitrobenzaldehyde in DMF/H2O (9:1) and in sole water.Figure optionsDownload high-quality image (87 K)Download as PowerPoint slideHighlights
► Zirconium phosphate/phosphonates-supported l-proline have been prepared.
► The solids tested on the asymmetric aldol addition in DMF/H2O 9:1 and in water.
► The hydrophobic groups on solid catalyst surface increasing the catalytic activity.
► High diastereoselectivity and high enantiomeric excess have been obtained.
Journal: Journal of Catalysis - Volume 282, Issue 1, 15 August 2011, Pages 112–119