کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6164064 1249459 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The use of immunoglobulin light chain assays in the diagnosis of paraprotein-related kidney disease
ترجمه فارسی عنوان
استفاده از آزمایشات زنجیره سبک ایمونوگلوبولین در تشخیص بیماری کلیوی مرتبط با پاراپروتئین
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
چکیده انگلیسی
Kidney involvement is common in paraprotein-related diseases. A diversity of clinical presentations and histopathological features can occur secondary to tissue injury caused by precipitation or deposition of a clonal immunoglobulin, usually an immunoglobulin light chain. The paraprotein is either produced by multiple myeloma or by a clone of B-cell lineage that does not fulfill diagnostic criteria for multiple myeloma. The recent introduction of serum immunoglobulin free light chain assays, which accurately quantify both light chain isotypes to produce a ratio that indicates the presence or absence of a light chain paraprotein, is a major clinical development. However, as the interpretation of the assay can be challenging, the aim of this review is to clarify the role of serum and urinary light chain assays in the screening and diagnosis of paraprotein-related kidney disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 87, Issue 4, April 2015, Pages 692-697
نویسندگان
, , , ,