کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6164070 1249459 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dendritic cells and innate immunity in kidney transplantation
ترجمه فارسی عنوان
سلولهای دندریتیک و ایمنی ذاتی در پیوند کلیه
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
چکیده انگلیسی
This review summarizes emerging concepts related to the roles of dendritic cells (DCs) and innate immunity in organ transplant rejection. First, it highlights the primary role that recipient, rather than donor, DCs have in rejection and reviews their origin and function in the transplanted kidney. Second, it introduces the novel concept that recognition of allogeneic non-self by host monocytes (referred to here as innate allorecognition) is necessary for initiating rejection by inducing monocyte differentiation into mature, antigen-presenting DCs. Both concepts provide opportunities for preventing rejection by targeting monocytes or DCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 87, Issue 4, April 2015, Pages 712-718
نویسندگان
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