کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6164681 | 1249479 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study
ترجمه فارسی عنوان
حلال اورامیک و خطر ابتلا به بیماری کلیوی در دیابت نوع 2: مطالعه متابولومیک
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کلمات کلیدی
نفروپاتی دیابتی، بیماری کلیوی در مرحله پایانی، مطالعه متابولیکی، توکسین اورامیک،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Here we studied plasma metabolomic profiles as determinants of progression to end-stage renal disease (ESRD) in patients with type 2 diabetes (T2D). This nested case-control study evaluated 40 cases who progressed to ESRD during 8-12 years of follow-up and 40 controls who remained alive without ESRD from the Joslin Kidney Study cohort. Controls were matched with cases for baseline clinical characteristics, although controls had slightly higher eGFR and lower levels of urinary albumin excretion than cases. Plasma metabolites at baseline were measured by mass spectrometry-based global metabolomic profiling. Of the named metabolites in the library, 262 were detected in at least 80% of the study patients. The metabolomic platform recognized 78 metabolites previously reported to be elevated in ESRD (uremic solutes). Sixteen were already elevated in the baseline plasma of our cases years before ESRD developed. Other uremic solutes were either not different or not commonly detectable. Essential amino acids and their derivatives were significantly depleted in the cases, whereas certain amino acid-derived acylcarnitines were increased. All findings remained statistically significant after adjustment for differences between study groups in albumin excretion rate, eGFR, or HbA1c. Uremic solute differences were confirmed by quantitative measurements. Thus, abnormal plasma concentrations of putative uremic solutes and essential amino acids either contribute to progression to ESRD or are a manifestation of an early stage(s) of the disease process that leads to ESRD in T2D.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 85, Issue 5, May 2014, Pages 1214-1224
Journal: Kidney International - Volume 85, Issue 5, May 2014, Pages 1214-1224
نویسندگان
Monika A. Niewczas, Tammy L. Sirich, Anna V. Mathew, Jan Skupien, Robert P. Mohney, James H. Warram, Adam Smiles, Xiaoping Huang, Walker Walker, Jaeman Byun, Edward D. Karoly, Elizabeth M. Kensicki, Gerard T. Berry, Joseph V. Bonventre,