Proof of Mechanism Study of a Novel Serotonin Transporter Blocker, DA-8031, Using [11C]DASB Positron Emission Tomography and In Vivo Microdialysis

These preclinical data provide a proof of mechanism for DA-8031 as a novel compound of targeting the SERT for the treatment of premature ejaculation, warranting further clinical trials. They also offer insight into the optimal drug dose needed to exert therapeutic effects while minimizing adverse effects in humans.