Polymorphisms in the P450 c17 (17-Hydroxylase/17, 20-Lyase) Gene: Association With Estradiol and Testosterone Concentration in Hypospadias

Our study suggests that, although polymorphism in CYP17 gene may not be associated with 17β-E2 and T concentrations in hypospadias cases, low levels of T and higher E2/T ratio might possibly act as risk factors for hypospadias.