کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6169360 | 1599351 | 2016 | 6 صفحه PDF | دانلود رایگان |
- In a retrospective multi-institutional Portuguese cohort study 40% of patients with early breast cancer had Stage I disease.
- Almost one-quarter of patients with pathological stage I breast cancer were treated with adjuvant chemotherapy.
- When treated with chemotherapy, most patients receive non-intensive regimens such as AC (doxorubicin plus cyclophosphamide).
- Taxane-based non-intensive regimens, such as TC (docetaxel plus cyclophosphamide), were infrequently used.
- Striking institutional variations in utilization of chemotherapy were noted, ranging from 0 to 43.4%.
BackgroundA contemporary US study showed an increase in the use of chemotherapy in the last decade for some patients with stage-I breast cancer; with a rise in more intensive regimens, and declining use of anthracyclines. Nevertheless, there is still uncertainty on the absolute benefit of chemotherapy for these patients and the optimal regimen. In this study we compare those findings with the patterns of care among a Portuguese cohort of stage-I breast cancers.MethodsRetrospective cohort study of patients with stage-I breast cancer diagnosed from 2006 to 2008 at four Portuguese institutions. The use and type of chemotherapy was evaluated.ResultsAmong patients with stage I-III breast cancer 39.4% (n = 682) had stage I disease. Of the 595 eligible patients, 22.4% were treated with chemotherapy, 33.9% aged <55 years vs. 12.7% aged >65 years (p < 0.001). Thirteen percent of patients with hormone receptor (HR)+/HER2â tumors, 52.7% of patients with HER2+ and 66.0% of patients with HR-/HER2â received chemotherapy (p < 0.001). In addition, we found inter-institutional variability, with the use of chemotherapy ranging from 0.0% to 43.4% (p < 0.001). Eighty-five percent of patients treated with chemotherapy received less-intensive regimens with anthracycline-based regimens, such as doxorubicin and cyclophosphamide, being the most frequently used, while docetaxel and cyclophosphamide was only used in 1.5% of cases.ConclusionsOverall, almost one-quarter of patients received chemotherapy with institutional variability. When treated, mostly less-intensive associations including anthracyclines were used, which contrasts with contemporary US practice. This study highlights the need for health-services research to understand local practices and tailor quality improvement interventions.
Journal: The Breast - Volume 29, October 2016, Pages 68-73