rs11895168 C allele and the increased risk of breast cancer in Isfahan population

- rs11895168 C allele is associated with increased risk of breast cancer.
- rs11895168 C allele is associated with positivity of ER/PR.
- rs11895168 C allele might upregulate ErbB4 by attenuating miR-1276:ErbB4 interaction.

ObjectivesSome of the single nucleotide polymorphisms in EebB4 gene have been studied to date in order for finding their relevance to the risk of breast cancer. However, no study has been conducted to investigate the importance of rs11895168, a microRNA-related SNP located in ErbB4 3′UTR, in breast tumors. In this paper, we investigated the frequency and association between rs11895168 and breast cancer.Materials and methodsThe rs11895168 was genotyped in 364 samples collected from 172 breast cancer patients and 192 healthy participants, using Tetra-primer ARMS PCR. The frequency of genotypes was analyzed to find the association between rs11895168 and breast cancer risk and also clinicopathological characteristics of patients.Resultsour in silico studies suggested that different alleles at rs11895168 affect the binding strength of miR-1276, a potential tumor suppressor. Statistical analysis showed a significant association between rs11895168 C allele-harboring genotypes and increased breast cancer risk.Conclusionrs11895168 C allele is strongly and significantly associated with the increased risk of breast cancer and positivity of ER/PR tumor cells.