کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6169623 1251178 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-sentinel lymph node analysis with one-step nucleic acid amplification in breast cancer patients
ترجمه فارسی عنوان
تجزیه و تحلیل گره لنفاوی غیرواقعی با تکثیر اسید نوکلئیک یک مرحله ای در بیماران مبتلا به سرطان پستان
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


- One-step nucleic acid amplification (OSNA) examines lymph node metastasis.
- Sentinel lymph node (SLN) biopsy is performed for breast cancer patient.
- A whole-node analysis of both SLN and non-SLN using the OSNA method was performed.
- Rates of positivity of non-SLN metastases in case of SLN metastasis were examined.
- Rates of non-SLN metastases were same regardless of the copy number of SLN.

BackgroundOne-step nucleic acid amplification (OSNA) examines lymph node metastasis in a semiquantitative manner with molecular biology techniques. In this study, we conducted a whole-node analysis of non-sentinel lymph nodes (SLNs) using the OSNA method in SLN metastasis-positive breast cancer patients.MethodsWith the OSNA method, we compared the rates of positivity of non-SLN metastasis in cases with both SLN micro- and macrometastases.ResultsThe rates of non-SLN metastasis positivity in those with SLN micrometastasis and macrometastasis were 44% and 48%, respectively, and this difference was not significant. When the study of non-SLN metastasis positivity was focused only on macrometastases, the rates of non-SLN metastasis positivity in patients with SLN micrometastasis and macrometastasis were 19% and 22%, respectively, and there was no significant difference.ConclusionRegardless of the copy number of SLN metastases, non-SLN metastases were found in approximately half of the cases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 24, Issue 4, August 2015, Pages 476-480
نویسندگان
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