کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6169623 | 1251178 | 2015 | 5 صفحه PDF | دانلود رایگان |
- One-step nucleic acid amplification (OSNA) examines lymph node metastasis.
- Sentinel lymph node (SLN) biopsy is performed for breast cancer patient.
- A whole-node analysis of both SLN and non-SLN using the OSNA method was performed.
- Rates of positivity of non-SLN metastases in case of SLN metastasis were examined.
- Rates of non-SLN metastases were same regardless of the copy number of SLN.
BackgroundOne-step nucleic acid amplification (OSNA) examines lymph node metastasis in a semiquantitative manner with molecular biology techniques. In this study, we conducted a whole-node analysis of non-sentinel lymph nodes (SLNs) using the OSNA method in SLN metastasis-positive breast cancer patients.MethodsWith the OSNA method, we compared the rates of positivity of non-SLN metastasis in cases with both SLN micro- and macrometastases.ResultsThe rates of non-SLN metastasis positivity in those with SLN micrometastasis and macrometastasis were 44% and 48%, respectively, and this difference was not significant. When the study of non-SLN metastasis positivity was focused only on macrometastases, the rates of non-SLN metastasis positivity in patients with SLN micrometastasis and macrometastasis were 19% and 22%, respectively, and there was no significant difference.ConclusionRegardless of the copy number of SLN metastases, non-SLN metastases were found in approximately half of the cases.
Journal: The Breast - Volume 24, Issue 4, August 2015, Pages 476-480