کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6169940 1251186 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tumor biology in older breast cancer patients - What is the impact on survival stratified for guideline adherence? A retrospective multi-centre cohort study of 5378 patients
ترجمه فارسی عنوان
زیست شناسی تومور در بیماران مبتلا به سرطان پستان بزرگتر - تاثیر بر بقا چیست برای پیروی از دستورالعمل چیست؟ یک مطالعه گذشته نگر چندگروه از 5378 بیمار
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

PurposeThe tumor biology of older breast cancer patients (oBCP) is usually less aggressive, however applied adjuvant treatment is often less potent resulting in an impaired disease free survival and overall survival in this group. This study tries to answer the following questions for the biological subtypes of oBCP (70+ y):(1)Is there a significant difference in the distribution of the biological subtypes of oBCP vs younger breast cancer patients (yBCP; 50-69 y)?(2)Which biological subtype has the highest rate of non-guideline-adherent-treatment (GL−) among oBCP?(3)Is a single GL− (i.e. radiotherapy/surgery/endocrine-therapy/chemotherapy) significantly associated with the survival outcome in each biological subgroup?MethodsBetween 1992 and 2008 the BRENDA ('BRENDA' = quality of BREast caNcer care unDer evidence-bAsed guidelines) study group recorded medical data of 17 participating certified breast cancer centers in Germany.We performed a retrospective multi-center database analysis of 5632 patient records. Guideline-adherent-treatment (GL+) of oBCP(n = 1918) was compared to GL+ of yBCP(n = 3714).ResultsOBCP were more likely to have hormone receptor positive (HR+) and HER2neu negative (HER2−) breast cancer (77.5% vs 74.5%). The rate of GL− was significantly different (p < 0.001) between the age groups and the biological subgroups (yBCP vs oBCP: 21.8%vs38.8% (HR+/HER2−); 30.6%vs49.7% (HR+/HER2+); 23.6%vs69.5% (HR−/HER2+); 31.4%vs67.8% (TNBC)).The survival parameters for HR+/HER2− and TNBC were significantly worse in case of GL− regarding chemotherapy, and if applicable endocrine therapy. A similar association only existed in HR−/HER2+ tumors for GL− for radiotherapy and in HR+/HER2+ tumors for chemotherapy.ConclusionsBeside the significantly different distribution of biological subtypes in the age groups there is an association between biological subtype, and GL+ influencing survival parameters in oBCP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 24, Issue 3, June 2015, Pages 256-262
نویسندگان
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