کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6170166 1251192 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Incidental radiation to axilla in early breast cancer treated with intensity modulated tangents and comparison with conventional and 3D conformal tangents
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Incidental radiation to axilla in early breast cancer treated with intensity modulated tangents and comparison with conventional and 3D conformal tangents
چکیده انگلیسی

PurposeTo analyze incidental radiation doses to minimally dissected axilla with Intensity modulated radiotherapy (IMRT), 3D conformal radiotherapy (3DCRT) and standard tangents (ST).Methods & materialsWe prospectively evaluated incidental radiation to axilla in fifty cases of early breast cancer treated with breast conservation surgery with sentinel node biopsy alone followed by whole breast irradiation with IMRT. Three plans were devised for each CT dataset, comprising ST, 3DCRT and IMRT tangents. Doses to axillary nodal levels I, II and III were evaluated for mean dose, V95, V90, V80 and V50. Comparisons were made using ANOVA.ResultsThe mean doses delivered to axilla by the three techniques (IMRT, 3DCRT, ST) were: 78% (range 67-90, SD ± 5.2%), 80% (63-95, ±7.5%) and 87% (73-98, ±4.8%) for level I (IMRT vs ST; p = 0.037); 70% (46-89, ±12.4%), 72% (34-93, ±15.5%) and 65% (29-87, ±11.8%) for level II; and 51% (28-76, ±11.1%), 53% (19-86, ±13.7%) and 41% (6-72, ±10.6%) for level III, respectively. V90 values (volume receiving 90% of dose) for the three techniques were 49% (43-53, ±2.7%), 57% (51-65, ±3.1%) and 73% (65-80, ±3.4%) for level I (IMRT vs ST; p = 0.029); 35% (26-42, ±4.7%), 41% (33-50, ±4.2%) and 25% (17-36, ±4.5%) for level II (IMRT vs ST; p = 0.068); and 15% (9-22, ±3.4%), 16% (10-24, ±3.7%) and 8 (5-12, ±3.1%) for level III (IMRT vs ST; p = 0.039), respectively.ConclusionAxillary levels I and II (lower axilla) receive substantial amount of incidental radiation doses with all the three techniques; however, conformal techniques (IMRT, 3DCRT) deliver significantly lesser incidental radiation to lower axilla than ST technique.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 22, Issue 6, December 2013, Pages 1125-1129
نویسندگان
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