Severe aortic or pulmonary valve stenosis in premature infants

Successful treatment of severe aortic (AS) or pulmonary valve (PS) stenosis by balloon valvuloplasty in term neonates is well-established. Sometimes, AS or PS diagnosed antenatally, progresses to severe left or right ventricular hypoplasia respectively. Successful fetal balloon valvuloplasty cannot be assumed to significantly change the natural history. In this review of premature infants, balloon valvuloplasty was used in extremely small babies. Five with severe AS (32 to 36 weeks, birth weight 1.4 to 1.9 kg) had percutaneous balloon aortic valvuloplasty during the first 10 days of life. Seven infants with severe/critical PS (28 to 36 weeks, birth weight 1.2 to 1.9 kg) had percutaneous balloon pulmonary valvuloplasty during the first 9 days of life. Two with pulmonary atresia (1.9 and 0.85 kg), underwent successful radiofrequency assisted balloon pulmonary valvuloplasty. There were no procedural deaths but one infant developed severe aortic insufficiency.