کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6172438 1599775 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The evaluation of endothelial function and structure in hirsute patients in reproductive age
ترجمه فارسی عنوان
بررسی عملکرد و ساختار اندوتلیال در بیماران هیرسوتیسم در سن باروری
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

ObjectiveTo evaluate the endothelial function and structure in patients with hirsutism in reproductive age.Study designThe study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Participants with modified Ferriman Gallway (mFG) score over 8 were considered to be hirsute. The demographic, metabolic, hormonal characteristics, risk factors of cardiovascular disease, CIMT (carotis intima media thickness) and FMD (flow-mediated dilatation) were compared between hirsute women and those in the control group. A prospective case-control study was performed.ResultsThere was no statistically significant difference in CIMT (0,50 ± 0,08 vs 0,52 ± 0,08, p = 0.38) and FMD (10,80 ± 6,83 vs 9,57 ± 6,52, p = 0.34) values between the study and control groups, respectively. There was no statistically significant correleation between CIMT and FMD values with age, body mass index (BMI), waist circumference, hip circumference, waist/hip ratio, CRP (C-reactive protein), total cholesterol, LDL (low density lipoprotein), HDL (high density lipoprotein), total testosteron, FAI (free androjen index), androstenedion, SHBG (sex hormone binding globuline), DHEA-S, hirsutism score, sistolic blood pressure, diastolic blood pressure, HOMA-IR (homeostatic model of assesment insuline resistance) value.ConclusionThe effect of the presence of hirsutism on either CIMT and FMD values, among young patients was not significant. Since endothelial dysfunction might became evident after a long period of physio-pathological process, our findings obtained from younger patients may not really show the impact of hirsutism on endothelial function in short term.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 206, November 2016, Pages 208-212
نویسندگان
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