کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6172776 1599778 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of gremlin-2 on the transition of primordial follicles during early folliculogenesis in the human ovary
ترجمه فارسی عنوان
اثرات گرمیلین-2 در انتقال فولیکول های اولیه به هنگام فولیکولوژنز زودرس در تخمدان های انسانی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

ObjectiveTo investigate the localization and function of gremlin-2 during human ovarian folliculogenesis.Study designOvarian tissue from a gynecologic cancer patient was cultured in the presence or absence of gremlin-2 and then analyzed histologically. Growing follicles were counted by the microscopic observations of ovarian histological sections. Immunocytochemical staining was carried out to detect the expression of bone morphogenetic protein (BMP) 4 and phosphorylated Smad 1/5/8 (p-Smad 1/5/8).ResultsGremlin-2 was detected in human primordial, primary, and early growing follicles before culture. By day 4 of culture, the follicle growth rate in the presence of gremlin-2 (13.7%; 24/175) was significantly lower than that of the control (54.8%; 92/175; p < 0.01). BMP4 expression was similar in the presence and absence of gremlin-2, whereas the p-Smad 1/5/8 signal was noticeably stronger in the absence of gremlin-2 in primordial and early-stage growing follicles.ConclusionsGremlin-2 maintains the follicle store as primordial follicles by suppressing Smad 1/5/8 signaling in the human ovary. The data presented here provide potential insight into reproductive medicine for cases of intractable infertility, such as premature ovarian insufficiency and cancer survivors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 203, August 2016, Pages 72-77
نویسندگان
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