The incidence of post-operative adhesion following transection of uterine septum: a cohort study comparing three different adjuvant therapies

ObjectiveTo investigate the clinical efficacy of postoperative estrogen therapy, intrauterine device (IUD) and intrauterine balloon in preventing intrauterine adhesions after transcervical resection of septum (TCRS).Study design238 patients who underwent TCRS in our hospital from March 2012 to December 2013 were allocated into one of four groups. In Group 1 (50 patients), women received postoperative estrogen therapy. In Group 2 (59 patients), an intrauterine contraceptive device (IUD) was placed into the uterine cavity at the end of the operation. In Group 3 (75 patients), a Foley catheter with the balloon inflated with 4 ml of normal saline solution was placed into the uterine cavity at the end of the operation for five days. In Group 4 (54 patients), women did not receive any of the above treatment (comparison group). All subjects underwent two further hysteroscopy, one and three months after the initial surgery.ResultsThe intrauterine adhesion rates among the four groups at one month were 22.0%, 28.81, 26.7% and 24.1% (p > 0.05); and at the third month were 0%, 1.7%, 1.3% and 3.4%, respectively (p > 0.05).ConclusionsThe use of postoperative estrogen therapy, IUD or intrauterine balloon did not appear to have any benefit in reducing the incidence of postoperative intrauterine adhesion formation.