کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6172985 | 1599798 | 2014 | 4 صفحه PDF | دانلود رایگان |
ObjectiveIs treatment of early pregnancy failure (EPF) with sequential use of mifepristone and misoprostol more effective than treatment with misoprostol alone?Study designIn a retrospective cohort study at the Department of Obstetrics and Gynaecology of the Radboud University Medical Centre, 301 women with early pregnancy failure receiving medical treatment between January 2008 and March 2013 were included. Of these, 199 women were pre-treated with 200Â mg mifepristone (orally) followed by 2 consecutive doses of 800Â mcg misoprostol (vaginally) and 102 women were treated with 2 consecutive doses of 800Â mcg misoprostol (vaginally) alone.ResultsComplete expulsion was achieved in 66.8% of the women treated with a sequential combination of mifepristone and misoprostol versus 54.9% of the women treated with misoprostol alone. The difference in rates of complete expulsion was 11.9% (PÂ <Â 0.05; 95% CI 0.3-23.6%).ConclusionsMedical treatment of early pregnancy failure with a sequential combination of mifepristone and misoprostol was more effective than treatment with misoprostol alone. Our findings will have to be confirmed by a large prospective multicentre double blinded-randomized trial.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 183, December 2014, Pages 16-19