Increased incidence of pelvic organ prolapse in women with acromegaly

ObjectiveTo evaluate gynecological problems of female patients with acromegaly and the relationship of these problems with the activity of the disease.Study designThirty-four women with acromegaly and 27 age- and body mass index-matched female healthy controls (HC) were included in the study. Demographic features, medical history, hormonal status and disease activity were obtained. A detailed gynecological examination was performed.ResultsThe incidence of pelvic organ prolapse (POP) was higher in patients with acromegaly (53%, n = 18) compared to the HC (15%, n = 4) (p = 0.003). Limiting the analysis to only cases with previous pregnancy, POP was seen in 18 (60%) of 30 cases with acromegaly and in 4 (20%) of 20 of the HC (p = 0.005). Additionally, in cases with prior vaginal delivery, POP was present in 18 (60%) of 30 cases with acromegaly and in 4 (24%) of 17 of the HC (p = 0.02). The frequency of POP was similar in patients with controlled and uncontrolled acromegaly (p = 0.3).ConclusionAcromegaly may facilitate occurrence of pelvic organ prolapse and may cause additional health issues in female cases.