Tubal sterilization: pregnancy rates after hysteroscopic versus laparoscopic sterilization in France, 2006-2010

ObjectiveTo compare the rates of pregnancy among women who underwent Essure® hysteroscopic sterilization versus tubal ligation in France between 2006 and 2010.Study designRetrospective cohort study.SettingHospital care in France (nationwide). Anonymised database of all hospital discharge summaries in France.PatientsRecruitment was based on procedure codes in the national database of hospital discharge summaries. The study included all women who underwent tubal sterilization by Essure® microinserts or by tubal ligation and subsequently were hospitalised either for all unexpected pregnancies related diagnosis (e.g., miscarriage, legal abortion, or delivery) or for pregnancies following reversal microsurgery or in vitro fertilization (IVF) treatment.Measurements and main resultsDuring the study period, French hospitals performed 109,277 tubal sterilization procedures: 39,169 Essure® sterilizations and 70,108 laparoscopic tubal ligations. The respective indication of both techniques depended on the surgeons' skill. The median age of the two populations was similar, 41 years (range 28-52) for Essure® patients and 40 years (range 27-54) for those undergoing tubal ligation (p = 0.42). A Cox model has been performed.Following sterilization, after adjustment on age Essure® patients became pregnant at a significantly lower rate than laparoscopic ligation patients 0.36% versus 0.46%, respectively (HR = 0.62 (040-096)), and their pregnancy rate of post-sterilization procedure was significantly lower (reversal microsurgeries: 0.02% versus 0.19% (p < 0.001), IVF treatment: 0.08% versus 0.27%) (p < 0.001). The pregnancy rates after IVF were 12.5% and 5.35%, respectively, and 0% and 11.36% after tubal repair.ConclusionThis nationwide study of tubal sterilization demonstrates that Essure® was associated with lower rates of pregnancy versus tubal ligation.