کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6173892 | 1599809 | 2014 | 4 صفحه PDF | دانلود رایگان |
ObjectiveLactobacilli have been found in the neovagina of very low numbers of transsexual women. We undertook this study to determine whether an orally administered preparation of four lactobacilli strains exerts some measurable effect on the neovaginal microflora of female transsexuals.Study design60 male to female transsexual women with penile linked neovagina were randomised into two groups. Women in the intervention group (n = 33) received oral probiotic capsules and women in the control group (n = 27) placebo in for 7 days. Swabs of the neovagina were taken before and after the therapy.ResultsComparing the first and second swabs, we observed a significant improvement of the Nugent score in the intervention group 16 (48.5%) vs. low improvement in control group 4 (14.8%) (p < 0.006). The neovaginal microflora was significantly enriched with lactobacilli after oral supplementation compared to placebo. In the intervention group, an increase by 10,000 ± 600 colony forming units (CFU) of presumptive lactobacilli was observed, compared with an increase by 1600 ± 100 CFU in the control group (p < 0.0001). When measured by real-time PCR (c/ml), lactobacilli increased by 1400 ± 100 c/ml in the intervention group and 300 ± 100 c/ml in the control group (p < 0.0001).ConclusionThere was an improvement of vaginal lactobacilli microflora after of oral supplementation with lactobacilli strains in transsexual women.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 172, January 2014, Pages 102-105