کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6174213 1599818 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sialidase activity in aerobic vaginitis is equal to levels during bacterial vaginosis
ترجمه فارسی عنوان
فعالیت سیلیداز در واژینیت هوازی برابر با سطوح واژینوز باکتریایی است
کلمات کلیدی
ایمنی مهلک واژن، واژینوز باکتریال، واژینیت هوازی سیتوکین، سیالیداز،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

ObjectiveTo evaluate levels of proinflammatory cytokines and sialidase activity in aerobic vaginitis (AV) in relation to normal vaginal flora and bacterial vaginosis (BV).Study designIn this cross-sectional study, a total of 682 consecutive non-pregnant women attending the gynecology service were assessed and 408 women were included. Vaginal rinsing samples were collected from 223 women with microscopic finding of BV (n = 98), aerobic vaginitis (n = 25) and normal flora (n = 100). Samples were tested for interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, and sialidase activity.ResultsCompared to women with normal flora, vaginal levels of IL-1β were highly increased in both BV and AV (p < 0.0001). Significantly higher vaginal IL-6 was detected in AV (p < 0.0001) but not in BV, in relation to normal flora. Women with AV also presented increased IL-8 levels (p < 0.001), while those with BV presented levels similar to normal flora. Sialidase was increased in BV and AV compared with the normal group (p < 0.0001) but no difference in sialidase activity was observed between BV and AV.ConclusionA more intense inflammatory host response occurs for AV than for BV when compared with normal flora. Furthermore, the increased sialidase activity in AV and BV indicates that both abnormal vaginal flora types can be harmful to the maintenance of a healthy vaginal environment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 167, Issue 2, April 2013, Pages 205-209
نویسندگان
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