کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6174711 | 1599831 | 2012 | 4 صفحه PDF | دانلود رایگان |

ObjectiveTo investigate the effect of carbon dioxide pneumoperitoneum on systemic oxidative stress by using serum oxidative stress markers (ischemia modified albumin (IMA), malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI)) and to compare their effectiveness at clinically accepted safe intra-abdominal pressure levels (<12 mmHg).Study designA total of 33 consecutive patients who had a unilateral ovarian cyst were enrolled for this prospective clinical study. All women underwent a laparoscopic ovarian cystectomy procedure. Venous blood was collected from patients preoperatively, 10 min after induction of anesthesia and 30 min after insufflation. Preoperative, 10min, and 30min serum IMA, MDA, TOS, OSI and TAS levels were compared.ResultsThe mean age was 29.3 ± 6.4 and the range of operation time was 45-80 min. The mean serum IMA levels showed a significant increase 30 min later from CO2 insufflation (p < 0.05). Significant alterations were not observed in serum MDA, TOS, OSI or TAS levels.ConclusionsLaparoscopic surgery causes systemic ischemia and this ischemic effect can be revealed by measuring serum ischemia modified albumin. IMA is more sensitive than MDA, TOS, OSI and TAS in early detection of systemic oxidative stress.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 161, Issue 1, March 2012, Pages 80-83