کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6174723 | 1599831 | 2012 | 6 صفحه PDF | دانلود رایگان |

ObjectivesTo evaluate the expression of different matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in vulvar lichen sclerosus (LS), a chronic dermatosis in women, histologically characterized by a zone of collagen remodeling in the superior dermis.Study designAnalysis of the expression of different MMPs (MMP-1, -2, -9 and -13) and TIMPs (TIMP-1 and -2) by reverse transcriptase-polymerase chain reaction (RT-PCR) in vulvar biopsies from patients with LS (n = 11), classified according to Hewitt histological criteria and compared with clinically normal vulvar tissue (n = 5), and the immunohistochemistry of MMP-2 and -9 and TIMP-1 and -2 distribution in the remodeling zone of LS (n = 31) and in clinically normal vulvar tissue (n = 28).ResultsAlthough no statistically significant difference between LS and normal skin groups at the mRNA level of MMP and TIMP transcripts was shown, an increase in the immunodistribution of MMP-2 and -9 and TIMP-1 and -2 in LS compared to normal vulvar skin was observed.ConclusionsThese results suggest that these molecules could be related to the process of cutaneous collagen remodeling in LS pathology.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 161, Issue 1, March 2012, Pages 96-101