First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids

ObjectiveTo study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.DesignRetrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.SettingAcademic hospital.Patient(s)Among the 52 patients, 21 wished to conceive upon treatment completion.Intervention(s)None.Main Outcome Measure(s)Pregnancy rate and live birth rate.Result(s)Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy.Conclusion(s)We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.