کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6179794 | 1253431 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Xenotransplantation of cryopreserved human ovarian tissue-a systematic review of MII oocyte maturation and discussion of it as a realistic option for restoring fertility after cancer treatment
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
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چکیده انگلیسی
Xenografting of human ovarian tissue has proved to be a useful model for examining ovarian function and follicle development in vivo. With human follicles that have matured through xenografting, the possibility of cancer transmission and relapse can also be eliminated, because cancer cells are not able to penetrate the zona pellucida. The reported studies have demonstrated that xenografted ovarian tissue from a range of species, including humans, can produce antral follicles that contain mature (MII) oocytes, and it has been shown that mice oocytes have the potential to give rise to live young. Although some ethical questions remain unresolved, xenotransplantation may be a promising method for restoring fertility. This review furthermore describes the value of xenotransplantation as a tool in reproductive biology and discusses the ethical and potential safety issues regarding ovarian tissue xenotransplantation as a means of recovering fertility.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 103, Issue 6, June 2015, Pages 1557-1565
Journal: Fertility and Sterility - Volume 103, Issue 6, June 2015, Pages 1557-1565
نویسندگان
Ralf Ph.D., Laura M.D., Tanja M.D., Jan M.D., Michael M.D., Bettina M.D., Hans Ph.D., Andreas N. M.D., Wolfgang M.D., Inge Hoffmann, Matthias W. M.D.,