کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6181491 1253510 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic variation of the E-cadherin gene is associated with primary infertility in patients with ovarian endometriosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Genetic variation of the E-cadherin gene is associated with primary infertility in patients with ovarian endometriosis
چکیده انگلیسی

ObjectiveTo explore the association between the genetic variant of E-cadherin gene and endometriosis-related infertility.DesignCase-control study.SettingUniversity hospital.Patient(s)Five hundred eighty-nine women with ovarian endometriosis including 127 patients with primary infertility and 589 female controls in northern China.Intervention(s)None.Main Outcome Measure(s)Single nucleotide polymorphisms (SNPs) in the promoter region, exons, and the 3′ untranslated region of the E-cadherin gene were identified by direct sequencing in patients with ovarian endometriosis and with polymerase chain reaction (PCR). Six candidate SNPs (rs16260, rs28372783, rs1801552, rs1801026, rs8049282, and rs13689) were genotyped by PCR and ligase detection reaction.Result(s)The results revealed a significant association of rs8049282 SNP on E-cadherin gene with endometriosis-related infertility. When compared with control women or endometriosis patients who had a history of successful fertility, the CC genotype of rs8049282 may significantly increase the risk of primary infertility in patients with ovarian endometriosis (adjusted odds ratio [OR] = 2.70, 95% confidence interval [CI] 1.45-5.00; OR = 2.54, 95% CI 1.45-4.44, respectively).Conclusion(s)Our results suggested that genetic variants on the E-cadherin gene may be involved in endometriosis-related infertility. The rs8049282 SNP of the E-cadherin gene may be a potential molecular marker for the development of primary infertility in northern Chinese women with ovarian endometriosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 102, Issue 4, October 2014, Pages 1149-1154.e1
نویسندگان
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