کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6182535 1253566 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Role of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas
چکیده انگلیسی
Elevated leiomyoma miR-21 levels are predicted to decrease PDCD-4 levels, thus leiomyomas differ from other tumors where loss of PDCD-4 is associated with tumor progression. Our studies indicate regulation of PDCD-4 expression is not a primary miR-21 function in leiomyomas, but instead miR-21 is able to impact cellular apoptosis and translation, through unknown targets, in a manner consistent with its involvement in the pathophysiology of uterine fibroids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 98, Issue 3, September 2012, Pages 726-734.e2
نویسندگان
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