کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6182701 | 1254032 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Neoadjuvant chemotherapy followed by robotic radical hysterectomy in locally advanced cervical cancer: A multi-institution study Neoadjuvant chemotherapy followed by robotic radical hysterectomy in locally advanced cervical cancer: A multi-institution study](/preview/png/6182701.png)
- Minimally invasive surgery is one of the most exciting areas of development in gynecologic oncology.
- Neo-adjuvant chemotherapy followed by radical surgery has become one of the alternatives to concomitant radio-chemotherapy.
- The development of robotic technology has facilitated the application of minimally invasive techniques in gynecologic oncology.
ObjectiveMinimally invasive surgery has been performed in locally advanced cervical cancer (LACC) without adverse effect in patient's overall prognosis and survival. The aim of this report is to evaluate the feasibility and morbidity of total robotic radical hysterectomy (TRRH) with pelvic lymphadenectomy in patients with LACC after neo-adjuvant chemotherapy (NACT).MethodsFrom February 2008 to April 2013 a retrospective data collection of women undergoing TRRH for cervical cancer stage FIGO IB2 to IIB, after neo-adjuvant chemotherapy, was conducted at “Regina Elena” National Cancer Institute of Rome and European Institute of Oncology of Milan. All patients deemed operable underwent TRRH with pelvic lymphadenectomy within 4Â weeks from the last chemotherapy cycle.ResultsMedian operative time was 225Â min (range, 105-387Â min). The median blood loss was 150Â mL (range, 30-700Â mL). The median number of removed pelvic lymph nodes was 23 (range, 8-69). Sixteen patients had an optimal response (12 PCR, 4 pPR1) to chemotherapy, 33 patients had a pPR2 and 11 patient showed stable disease. Adjuvant therapy was administrated in 36 patients (60%). We experienced one intra-operative complication and 19 post-operative complications, but no conversions to laparotomy were necessary to manage these complications. Six patients received a blood transfusion. At the time of this report, with a median follow-up of 28.9Â months, 50 patients (83%) are free from recurrence.ConclusionThis experience demonstrates the feasibility of TRRH pelvic lymphadenectomy after NACT in LACC with good accuracy and safety.
Journal: Gynecologic Oncology - Volume 133, Issue 2, May 2014, Pages 180-185