کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6182820 1254037 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ovary and uterus-sparing procedures for low-grade endometrial stromal sarcoma: A retrospective study of 153 cases
ترجمه فارسی عنوان
روشهای تخفیف تخمدان و رحم برای سارکوم استرومال اندومتر کم: یک مطالعه گذشته نگر از 153 مورد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


- Hysterectomy with bilateral salpingo-oophorectomy and complete resection of the macroscopic lesion should be treated as the mainstay treatments for LG-ESS.
- Ovary-sparing procedures could be considered for young women without cervical involvement; however, long-term follow-up should be mandatory.
- Myomectomy should only be conserved for young patients with a strong desire for future fertility, with fully informed consent.

ObjectiveTo discuss the optimal treatment options for low grade endometrial stromal sarcoma (LG-ESS).MethodsMedical records of consecutive patients with LG-ESS in our institute were collected. The pertinent data, including clinicopathological characteristics, treatment and prognostic information were evaluated.ResultsA total of 153 cases of LG-ESS were included. The 5-year relapse free survival (RFS), overall survival (OS) and survival after relapse (SAR) rates were 66.1%, 95.8% and 82.9%, respectively. Ovary-sparing procedures, positive resection-margins, and myomectomy were the independent adverse factors for relapse (P < 0.0001, = 0.0041, and = 0.0075, respectively). Post-menopause, cervical involvement, and positive lymphovascular space involvement were significantly associated with survival (P < 0.0001, = 0.0020, and = 0.0163, respectively). Distance recurrence and macroscopically residual tumors negatively affected SAR (P = 0.0137 and = 0.0004, respectively). No benefit was found for lymphadenectomy in terms of both RFS and OS (P = 0.1187 and = 0.5138, respectively). Initial ovary-sparing procedures and myomectomy had no impact on OS (P = 0.0810 and = 0.8845, respectively). Adjuvant treatment had a slightly beneficial effect both on OS and SAR.ConclusionHysterectomy with bilateral salpingo-oophorectomy and complete resection of the macroscopic lesion should be treated as the initial and salvage mainstay treatments for LG-ESS patients. Ovary-sparing procedures could be considered for young women without cervical involvement; however, long-term follow-up should be mandatory. Myomectomy should only be conserved for young patients with a strong desire for future fertility, with fully informed consent; hysterectomy was recommended after the completion of pregnancy and delivery. However, the roles of lymphadenectomy and adjuvant treatment deserve further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 132, Issue 3, March 2014, Pages 654-660
نویسندگان
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