کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6182972 1254057 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prognostic significance of an early decline in serum alpha-fetoprotein during chemotherapy for ovarian yolk sac tumors
ترجمه فارسی عنوان
اهمیت پیش آگهی کاهش زودرس آلفا فتئوپروتئین سرم در طی شیمیدرمانی برای تومورهای ساق تخمدان زرد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


- Ovarian yolk sac tumors (OYST) belong to ovarian germ cell tumors.
- Elevated serum alpha-fetoprotein (AFP) is one of the hallmarks of OYSTs.
- Following surgery, BEP chemotherapy has become the standard of care in OYSTs.
- Serum AFP decline between baseline and day 21 is an independent prognostic factor.
- This may help to select patients for risk-adapted chemotherapy treatment.

BackgroundThe ovarian yolk sac tumor (OYST) is a very rare malignancy arising in young women. Our objective was to determine whether an early decline in serum alpha-fetoprotein (AFP) during chemotherapy has a prognostic impact.MethodsThis retrospective study is based on prospectively recorded OYST cases at Gustave Roussy (Cancer Treatment Center). Survival curves were estimated using the Kaplan-Meier method. The serum AFP decline was calculated with the formula previously developed and validated in male patients with poor prognosis non-seminomatous germ cell tumors. Univariate and multivariate analyses were performed using the log-rank test and logistic regression, respectively.ResultsData on AFP were available to calculate an early AFP decline in 57 patients. All patients had undergone surgery followed by chemotherapy. The 5-year overall survival (OS) and event-free survival (EFS) rates were 86% (95% CI: 74%-93%) and 84% (95% CI: 73%-91%), respectively. The disease stage, presence of ascites at presentation, use of the BEP regimen, serum AFP half-life and an early AFP decline were significantly predictive factors for OS and EFS in the univariate analysis. The OS rate was 100% and 49% (95% CI: 26%-72%) in patients with a favorable AFP decline and in those with an unfavorable decline, respectively (p < 0.001). In the multivariate analysis, only the presence of ascites at diagnosis (RR = 7.3, p = 0.03) and an unfavorable early AFP decline (RR = 16.9, p < 0.01) were significant negative predictive factors for OS.ConclusionsAn early AFP decline during chemotherapy is an independent prognostic factor in patients with OYSTs.Conflict of interest statementNo conflict of interest

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 142, Issue 3, September 2016, Pages 452-457
نویسندگان
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