The effects of 17β-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis

► 17β-estradiol increases invasion and proliferation of ovarian cancer in vitro. ► The effects of 17β-estradiol are reversed by a 3rd generation SERM, bazedoxifene. ► Neither 17β-estradiol nor bazedoxifene changes tumor burden in genetic mouse model.