Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer

► We investigated the expression of mTOR signaling molecules in ovarian cancer. ► Immunohistochemistry was done with antibodies against p-4EBP1, p-mTOR, and p-p70S6K. ► p-4EBP1 expression was associated with poor prognostic factors of ovarian cancer. ► p-4EBP1 overexpression may be a prognostic biomarker of ovarian cancer.