کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6183918 | 1254146 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The incidence of isolated para-aortic nodal metastasis in completely staged endometrial cancer patients The incidence of isolated para-aortic nodal metastasis in completely staged endometrial cancer patients](/preview/png/6183918.png)
ObjectiveTo describe and review the incidence of para-aortic (PA) nodal metastasis in completely staged endometrial cancer patients who are negative for pelvic nodal metastasis.MethodsUsing an institutionally maintained database, we identified all patients with endometrial cancer from 2002 to 2006 who had both pelvic and aortic nodal dissections and determined the rate of isolated para-aortic nodal metastasis in non-malignant (i.e. negative) pelvic nodes.Results201 endometrial cancer patients were surgically treated at our institution from 2002 to 2006. 171 patients had both pelvic and PA nodes removed during surgery, and specimens examined by a pathologist. Only 2 (1.2%) had PA nodes that tested positive for malignance (i.e. positive PA nodes) with pelvic nodes that tested negative for malignance (i.e. negative pelvic nodes). The final International Federation of Gynecology and Obstetrics (FIGO) grade for the endometrial tumor cells in the two patients was “G1” with endometrioid adenocarcinoma and “G3” with endometrioid adenocarcinoma and mucinous differentiation, respectively.ConclusionBased on the very low incidence of patients inflicted with endometrial cancer that have positive para-aortic lymph nodes (PALNs) with negative pelvic nodes found both in our literature review (1.5%) and in our own study (1.2%), the addition of PA lymphadenectomy in all patients was found to have minimal diagnostic and therapeutic value. At the present, the role of complete PA lymphadenectomy in all patients with endometrial cancer should be re-examined. Individualized algorithms should be developed based on risk factors and status of pelvic nodes.
Research Highlights⺠Isolated para-aortic lymph node metastases in endometrial cancer are uncommon. ⺠Individualized para-aortic lymphadenectomy is recommended for this disease. ⺠Para-aortic lymph node involvement does not appear to be an independent risk factor.
Journal: Gynecologic Oncology - Volume 121, Issue 1, April 2011, Pages 122-125