Anti-tumor activity of an anti-DR5 monoclonal antibody, TRA-8, in combination with taxane/platinum-based chemotherapy in an ovarian cancer model

► Combination treatment with chemotherapy and TRA-8 significantly inhibits cell viability in vitro. ► TRA-8 and chemotherapy prolong survival in an ovarian cancer model. ► Treatment with chemotherapy + TRA-8 resulted in high levels of caspase-3 and PARP cleavage.