Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance

► We have elaborated on functional roles of ovarian cancer‐specific kallikreins due to regulation of integrin expression and cell adhesion. ► Paclitaxel‐insensitivity of KLK‐expressing cancer cells was accompanied by differential expression of drug‐resistance‐genes, indicative of disease progression. ► These key findings provide new mechanistic insight into peritoneal spread and chemoresistance of advanced ovarian cancer.