کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6185166 | 1254355 | 2014 | 5 صفحه PDF | دانلود رایگان |
- We found no evidence that IORT changes survival outcomes and recurrence.
- Indications for IORT at PE confer worse prognosis, perhaps due to tumor laterality.
- Careful patient selection is critical as IORT is unlikely to overcome sidewall extension.
ObjectiveTo determine whether intra-operative radiation therapy (IORT) at the time of pelvic exenteration (PE) or laterally extended endopelvic resection (LEER) improves progression-free survival (PFS) in patients with recurrent, previously irradiated gynecologic cancers.MethodsWe conducted a single institution retrospective review of patients who had undergone a complete PE for locally recurrent gynecologic cancer. Demographic and clinicopathologic data were collected.Results32 patients were identified (2000-2012); 21 (66%) cervical cancer, 8 (25%) vaginal, and 3 (9%) vulvar cancer. All patients were previously irradiated. Twenty-one (66%) received IORT. Mean age was 51. Eight patients had a LEER, all with IORT. Median PFS and OS, respectively, for those with PE alone was 33 and 41 vs. 10 and 10Â months for PEÂ +Â IORT compared to 9 and 17Â months for LEERÂ +Â IORT (PÂ =Â .04). Increasing tumor size negatively impacted PFS (hazard ratio 1.3; 95%CI 1.12-1.52). Margin status was not associated with survival. No patients undergoing LEERÂ +Â IORT recurred only locally whereas 62% recurred with a distant component (+/â local). Patients with PE alone had mainly local (36%) and few (9%) distant recurrences compared to 31% local and 38% distant (+/â local) recurrences for those with PEÂ +Â IORT.ConclusionsWe failed to demonstrate that IORT changes survival and recurrence outcomes. However, patients with clinical indications for IORT at the time of PE have worse prognosis compared to those who do not require IORT. If the need for IORT is anticipated, the surgeon may consider performing a LEER to decrease local recurrence if cure is the goal or consider palliative treatment options.
Journal: Gynecologic Oncology - Volume 135, Issue 1, October 2014, Pages 95-99