کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6185209 1254376 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interferon-gamma in ascites could be a predictive biomarker of outcome in ovarian carcinoma
ترجمه فارسی عنوان
اینترفرون گاما در آسیت می تواند یک شاخص زیست شناسی پیش بینی کننده در نتیجه کارسینوم تخمدان باشد
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


- Patients with ovarian cancer and high IFN-γ expression levels in cancer-associated ascites have poorer clinico-pathologic characteristics and survival.
- IFN-γ expression level could be an immunologically predictive biomarker for ovarian carcinoma.

ObjectiveThe ovarian cancer-associated ascites is an ideal material for evaluating the interaction between the host immune system and cancer cells in the tumor micro-environment. The aim of this study was to investigate whether the selected target cytokine expression levels in ascites could serve as an immune biomarker for predicting outcomes in ovarian cancer.MethodsEighty-eight specimens of ovarian cancer-associated ascites were evaluated to select the target cytokine by a cytokine profiling kit. The 144 total samples were subsequently analyzed for this target cytokine. The correlation between the target cytokine and clinical characteristics was analyzed.ResultsInterferon-gamma (IFN-γ) was identified as the target cytokine. Higher levels of IFN-γ in the ascites of the tumor micro-environment were associated with advanced disease (p = 0.012), higher tumor histological grading (p = 0.004), and sub-optimal surgical status (p = 0.040). By multivariate analysis, the adjusted hazard ratios (HRs) were 2.74 (95% confidence interval (CI) 1.85-4.05, p < 0.001) for disease-free survival (DFS) and 1.72 (95% CI 1.01-2.93, p = 0.048) for overall survival (OS) for a 10-fold increase in IFN-γ concentration in the ascites. An inverse dose-response relationship between IFN-γ level and survival was also noted (Ptrend < 0.001 for DFS and Ptrend < 0.042 for OS).ConclusionsPatients with ovarian cancer and higher IFN-γ expression levels in cancer-associated ascites will have shorter DFS and OS. IFN-γ levels in the ascites may be a prognostic marker and a potential reference for immunotherapy targeting IFN-γ.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 131, Issue 1, October 2013, Pages 63-68
نویسندگان
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