کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6185830 1254386 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The value of 18F-FDG PET/CT in recurrent gynecologic malignancies prior to pelvic exenteration
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The value of 18F-FDG PET/CT in recurrent gynecologic malignancies prior to pelvic exenteration
چکیده انگلیسی

ObjectiveIn patients undergoing pelvic exenteration for recurrent gynecological malignancies, we assessed the performance of [18F]-FDG PET/CT for delineating disease extent and evaluated the association between quantitative FDG uptake metrics (SUVmax, total lesion glycolysis [TLG] and metabolic tumor volume [MTV]) and progression-free survival (PFS) and overall survival (OS).MethodsRetrospective study of patients undergoing pelvic exenteration for gynecologic malignancies between January 2002 and November 2011 who had FDG PET/CT within 90 days before surgery. Two readers (R1, R2) independently determined the presence of bladder, rectum, vagina, cervix and pelvic side wall invasion and measured SUVmax, TLG and MTV in each patient. Areas under the curve (AUCs), for detecting organ invasion were calculated. Kaplan-Meier graphs were used to determine associations between FDG uptake and PFS/OS. Inter-reader agreement was assessed.Results33 patients (mean age 56 years, range: 28-81) were included; primary sites of disease were the cervix (n = 18), uterus (n = 8) and vagina/vulva (n = 7). AUCs for organ invasion ranged from 0.74 to 0.96. There was a significant association between FDG uptake metrics incorporating tumor volume (TLG and MTV) and OS (p ≤ 0.001) as well as between MTV and PFS (p = 0.001). No significant association was identified between SUVmax and OS/PFS (p = 0.604/0.652). Inter-reader agreement for organ invasion was fair to substantial (k = 0.36-0.74) and almost perfect for FDG quantification (ICC = 0.97-0.99).ConclusionIn patients undergoing pelvic exenteration for recurrent gynecological malignancies, 18F-FDG PET/CT is useful for preoperative assessment of disease extent. Furthermore, quantitative metrics of FDG uptake incorporating MTV serve as predictive biomarkers of progression-free and overall survival in this population.

► FDG PET/CT had high accuracy for the evaluation of disease extent prior to pelvic exenteration for recurrent gynecological cancer. ► FDG uptake metrics incorporating tumor volume (total lesion glycolysis and metabolic tumor volume) are significantly associated with overall survival. ► No significant association was identified between SUVmaxand overall survival.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 129, Issue 3, June 2013, Pages 586-592
نویسندگان
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