Cumulative delivery rates after ICSI with donor spermatozoa in different age groups

This retrospective cohort study followed a total of 364 women were followed from their first fresh, donor ICSI cycle for up to six ICSI cycles. All patients started their treatment between January 2003 and December 2007. Live birth delivery after 25 weeks of gestation was the main outcome measure of our study. All patients without a delivery after 25 weeks in an ICSI cycle were eligible for a subsequent cycle, including patients with cancelled cycles and those with a pregnancy that did not result in a live birth. The overall expected cumulative delivery rate after six ICSI cycles was 90% (95% confidence interval, CI, 86-94%). In women aged 38-39 years, the crude and expected cumulative delivery rates after six cycles were 54% (95% CI 43-66%) and 82% (95% CI 67-97%), respectively. In women aged 30-37 years, the crude and expected cumulative delivery rates after six cycles were 66% (95% CI 60-72%) and 91% (95% CI 86-96%), respectively. In women aged 20-29 years the crude and expected cumulative delivery rates after six cycles were 81% (95% CI 71-90%) and 93% (95% CI 86-100%), respectively. No significant difference was found between the cumulative delivery rates of patients who had a primary ICSI treatment (no previous intrauterine insemination) and patients who had previous intrauterine insemination. Our study corroborates the impact of age on ICSI with donor spermatozoa.