کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6215145 | 1606499 | 2012 | 5 صفحه PDF | دانلود رایگان |
FMS-like tyrosine kinase 3 (FLT3) mutation in T lymphoblastic leukemia/lymphoma (T-LL) is rare (â¼4%) and reported only in cases with CD117 expression. This study aimed to identify the immunophenotypic features that may predict FLT3 mutations. We report 3 (43%) of 7 CD117+ T-LL cases harboring FLT3-internal tandem duplication mutation. Compared with 4 FLT3-unmutated cases, all 3 FLT3-mutated cases had a distinct immunophenotype (CD1aâ/CD2+/CD7+/CD34+/CD117uniform+/Tdt+) corresponding to the stage of earliest thymic T-cell progenitors possessing myeloid lineage potential. Indeed, all FLT3-mutated T-LL cases expressed myeloperoxidase on a very small subset of blasts and, thus, may be further considered a mixed phenotype acute leukemia, T/myeloid, by the 2008 World Health Organization classification scheme. We conclude that this unique immunophenotype (CD1aâ/CD2+/CD7+/CD34+/CD117+/Tdt+) is a better predictor of FLT3 mutation than sole CD117 expression.
Journal: Annals of Diagnostic Pathology - Volume 16, Issue 1, January 2012, Pages 16-20