کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6215609 | 1271392 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low-grade small round cell tumor of the cauda equina with EWSR1-WT1 fusion and indolent clinical course
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
SummaryWe report a case of a longstanding, large tumor involving spinal nerve roots of the cauda equina. The tumor showed small round cells arranged in nests and cords and immunophenotypic features of a glomus tumor, along with infrequent mitoses and a low Ki-67 labeling index, but exhibited some rosette-like structures, with focal CD99 and Neu-N expression. Subsequent molecular analysis showed the presence of an EWSR1-WT1 gene fusion by fluorescence in situ hybridization, which was confirmed by reverse- transcriptase polymerase chain reaction. To our knowledge, this is the first case reported with EWSR1-WT1 fusion in a small round blue cell tumor with smooth muscle differentiation and an indolent course.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 46, Issue 1, January 2015, Pages 153-158
Journal: Human Pathology - Volume 46, Issue 1, January 2015, Pages 153-158
نویسندگان
Nasir MBBS, FCPS, Melike MD, Gohar MBBS, FCPS, Andrew E. MD, PhD, Zubair MBBS, FCPS, Muhammad MBBS, Anthony L. BSc, Dolores MD, PhD, Arie MD,