کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6215665 1271400 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A comparison of cervical histopathology variability using whole slide digitized images versus glass slides: experience with a statewide registry
ترجمه فارسی عنوان
مقایسه تغییرات هیستوپاتولوژی گردنی با استفاده از تصاویر دیجیتالی تمام اسلیدی در مقابل اسلاید های کشویی: تجربه با رجیستری دولتی
کلمات کلیدی
نئوپلاسی داخل رحم سرویکس، تصویربرداری کامل اسلاید، آسیب شناسی بالینی، قابلیت اطمینان، ثبت نام
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی

SummaryWhole slide imaging is increasingly used for primary and consultative diagnoses, teaching, telepathology, slide sharing, and archiving. We compared pathologist evaluations of glass slides and corresponding digitized images within the context of a statewide surveillance effort. Cervical specimens collected by the New Mexico HPV Pap Registry research program targeted cases diagnosed between 2006 and 2010. Two samples of 250 slides each were digitized with the ScanScope XT (Aperio, Vista, CA) microscope and reviewed with Aperio ImageScope reader. (1) A “random set” had a distribution of community diagnoses: 70% from cases of cervical intraepithelial neoplasia grade 2 or higher, 20% from cases of cervical intraepithelial neoplasia grade 1 and 10% from negative cases. (2) A “discrepant set” was represented by difficult cases where 2 study pathologists initially disagreed. Within the regular workflow of the New Mexico HPV Pap Registry, 3 pathologists read the slides 2 to 3 times each without knowledge of clinical history, previous readings or sampling scheme. Pathologists also read each corresponding image twice. For within- and between-reader comparisons we calculated unweighted κ statistics and asymmetry χ2 tests. Across all comparisons, slides and images yielded similar results. For the random set, almost all within-reader and between-reader Kappa values ranged between 0.7 and 0.8 and 0.6 and 0.7, respectively. For the discrepant set, most within- and between-reader κ values were 0.4 to 0.6. As cervical intraepithelial neoplasia diagnostic terminology changes, pathologists may need to re-read histopathology slides to compare disease trends over time, eg, before/after introduction of human papillomavirus vaccination. Diagnosis of cervical intraepithelial neoplasia differed little between slides and corresponding digitized images.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 44, Issue 11, November 2013, Pages 2542-2548
نویسندگان
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