کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6216740 | 1607093 | 2015 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mortality and morbidity in primarily resected hepatoblastomas in Japan: Experience of the JPLT (Japanese Study Group for Pediatric Liver Tumor) trials Mortality and morbidity in primarily resected hepatoblastomas in Japan: Experience of the JPLT (Japanese Study Group for Pediatric Liver Tumor) trials](/preview/png/6216740.png)
BackgroundIn the Japanese Study Group for Pediatric Liver Tumor (JPLT) protocols (JPLT-1 and 2) for evaluating the cure rate of risk-stratified hepatoblastoma, primary resection was permitted in PRETEXT I and II cases, followed by postoperative chemotherapy.MethodsIn approximately 500 enrolled cases, resection was performed as the initial treatment in 60 cases, including all 18 PRETEXT I, 30 PRETEXT II, and 12 ruptured cases. The clinical features, surgical procedures, complications, and survival rates were compared in these three groups.ResultsAll 18 PRETEXT I cases underwent complete resection by lobectomy or segmentectomy (n = 14) or nonanatomical partial hepatectomy (NPH) (n = 4). The 30 PRETEXT II cases underwent primary resection by right or left lobectomy (n = 16), NPH (n = 10), or other procedures (n = 4). Of these 30 cases, operational death occurred in 1 newborn, and recurrence occurred in 7 cases (14.6%), including 6 NPH cases and 4 older cases (aged > 3 years). Of the 12 ruptured cases, 7 (58.3%) showed recurrence. Event-free survival rates at 5 years in the 3 groups were 88%, 70%, and 32%, respectively.ConclusionsPrimary resection for PRETEXT I or II HB cases should be performed by anatomical resection according to strict surgical guidelines. More intensified chemotherapy is required for primary resected cases whose tumors have ruptured.
Journal: Journal of Pediatric Surgery - Volume 50, Issue 12, December 2015, Pages 2098-2101